<?xml version="1.0" encoding="UTF-8"?>
<urlset xmlns="http://www.sitemaps.org/schemas/sitemap/0.9" xmlns:image="http://www.google.com/schemas/sitemap-image/1.1" xmlns:xhtml="http://www.w3.org/1999/xhtml">
  <url>
    <loc>https://www.millerlabmgh.org/team</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2025-10-14</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/93fa5403-9aae-4964-9d04-3c0f02b56f97/PGM+Photo+3.jpg</image:loc>
      <image:title>Miller Lab Team Members - Peter Miller, MD, PhD</image:title>
      <image:caption>Principal Investigator Peter Miller grew up in Atlanta, Georgia and moved to Cambridge, Massachusetts after high school where he completed his undergraduate degrees in Chemical Engineering and Biology at the Massachusetts Institute of Technology. He completed his MD and PhD at Harvard Medical School and Harvard University where he studied leukemia stem cell biology in the laboratories of Gary Gilliland and Benjamin Ebert. After graduation, he completed an internal medicine residency at Brigham and Women’s Hospital and a fellowship in Medical Oncology and Hematology at the Dana-Farber Cancer Institute / Massachusetts General Hospital combined program. Peter performed his postdoctoral work in Ben Ebert’s lab at the Dana Farber Cancer Institute and Broad Institute. His research focuses on the biology of myeloid malignancies and he is an Assistant Professor at Harvard Medical School and member of the leukemia program at the Massachusetts General Hospital Center for Cancer Research.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/1644004904471-28DXONFQZ1ON2HKIG46B/Nicole+Smith.png</image:loc>
      <image:title>Miller Lab Team Members</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/1644004947099-WYJWPQQ8JJTJFL17RBI3/cheryl+Crowley+photo.jpg</image:loc>
      <image:title>Miller Lab Team Members</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/1656695515627-G3CFM8XGCLT5SBN1MLB6/Lexi.JPG</image:loc>
      <image:title>Miller Lab Team Members</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/370b84ec-fb9e-4a11-b79d-774297bfe79a/Weixin+Image_20230627132948.jpg</image:loc>
      <image:title>Miller Lab Team Members</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/7725ccff-b9ff-49f4-9f54-9897ed383859/processed-e7ede86a-8eb3-4429-aae9-0ef39ba3ea73_sp2JeBQt+%281%29.jpg</image:loc>
      <image:title>Miller Lab Team Members</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/9d81537b-705a-4a1a-920d-39291e7c766a/c6534ff0-38d0-4801-9744-268211344670.jpg</image:loc>
      <image:title>Miller Lab Team Members</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/43a073a5-7bf8-4da9-807d-bedbe6ab9b3f/IMG_4845.jpg</image:loc>
      <image:title>Miller Lab Team Members</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/9645f5f6-7372-4e05-883c-6e05a2279e4c/Sita+Photo.jpg</image:loc>
      <image:title>Miller Lab Team Members</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/210b50b5-800b-4985-89de-27ff1ebf476b/Hatem.jpg</image:loc>
      <image:title>Miller Lab Team Members</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/0bf8d5b3-1b14-4885-935b-bd8f384a64cf/Cam+Schluter.JPG</image:loc>
      <image:title>Miller Lab Team Members</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/9c018e08-5547-4c61-82fa-7360f70fe170/Nabila+Saker.jpg</image:loc>
      <image:title>Miller Lab Team Members</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/200a6216-8f32-4ea3-ab95-7925a977b750/Avery_Website_MillerLab.png</image:loc>
      <image:title>Miller Lab Team Members</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/13e6f6eb-8600-4318-8e42-729fc73c9ddd/Picture_GJ.jpg</image:loc>
      <image:title>Miller Lab Team Members</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/78a3ebd3-6768-4d32-a5a4-1c3b81bc6576/Ruxin.jpg</image:loc>
      <image:title>Miller Lab Team Members</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/44abbbb7-8329-4ba6-bd17-bbdc881325a0/Ashwini+copy.jpg</image:loc>
      <image:title>Miller Lab Team Members</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/a3ddd49f-68c4-4e6d-92e9-57ae38f51173/Tharshika.jpg</image:loc>
      <image:title>Miller Lab Team Members</image:title>
    </image:image>
  </url>
  <url>
    <loc>https://www.millerlabmgh.org/ppm1d-ddr</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2023-05-11</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/f4d94013-373f-4312-9602-389495f24eb5/CHIP+in+CART.jpg</image:loc>
      <image:title>PPM1D and the DNA Damage Response - PPM1D Mutations Are Common after Chemotherapy</image:title>
      <image:caption>Numerous studies have now confirmed that individuals with clonal hematopoiesis, myelodysplastic syndrome (MDS), or acute myeloid leukemia (AML) who have previously been exposed to chemotherapy or radiation are significantly more likely to have a mutation in a gene involved in the DNA damage response (DDR). Among this group of genes, PPM1D is the most-commonly mutated, with recurrent truncating mutations occurring in the c-terminus of the protein (1).</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/bd8bfe9e-a57c-4ca9-aa3f-3a7fca23d5ae/PPM1D+Homology+Model.jpg</image:loc>
      <image:title>PPM1D and the DNA Damage Response - PPM1D Truncations Impair Degradation</image:title>
      <image:caption>We have previously shown that the c-terminus of PPM1D encodes for a degradation signal by the proteasome. Therefore, loss of the c-terminus of PPM1D via truncating mutations impair proteasomal degradation and increase intracellular levels of the protein. These elevated levels in turn suppress the DNA damage response and p53 activation allowing cells harboring these truncating mutations to be more resistant to chemotherapy relative to non-mutant cells (2).</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/9f8f7433-8f68-4227-8567-cf0bca8c0caa/DDR+PPM1D.jpg</image:loc>
      <image:title>PPM1D and the DNA Damage Response - PPM1D as a Therapeutic Target in Cancer</image:title>
      <image:caption>We have now developed numerous new tools to interrogate these findings and are now working to more deeply explore numerous aspects of PPM1D biology, ranging from fundamental structure-functional studies of PPM1D to therapeutic studies in vivo. We believe that these lines of inquiry are required to understand the biology of PPM1D, the stem cell response to genotoxic stress, and the potential of PPM1D as a drug target in cancer.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.millerlabmgh.org/mutational-landscape</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2023-05-11</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/548bdc85-a638-465d-8009-0830dd6f168b/CHIP+as+Screen.jpg</image:loc>
      <image:title>Mutational Landscape of Clonal Hematopoiesis and Myeloid Malignancies - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/0278c112-171c-4141-a215-abd790df41b5/CHIP+in+CART.jpg</image:loc>
      <image:title>Mutational Landscape of Clonal Hematopoiesis and Myeloid Malignancies - Clonal Hematopoiesis, MDS, Leukemia, and Cancer Therapy</image:title>
      <image:caption>In patients heavily pretreated for lymphoma or myeloma, we found that exposure to chemotherapy and radiation selects for mutation in genes involved in the DNA damage response including PPM1D and TP53 whereas exposure to immune checkpoint blockade does not (1,2). We are extending these studies to understand how these mutations ultimately lead to the development of myelodysplastic syndrome and leukemia.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.millerlabmgh.org/contact</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2022-01-09</lastmod>
  </url>
  <url>
    <loc>https://www.millerlabmgh.org/positions</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2022-07-27</lastmod>
  </url>
  <url>
    <loc>https://www.millerlabmgh.org/support</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2022-01-08</lastmod>
  </url>
  <url>
    <loc>https://www.millerlabmgh.org/chip-and-inflammation</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2023-06-13</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/92f02a6e-2edd-4ba7-9ac0-76aec824304a/Emphysema+Mice.jpg</image:loc>
      <image:title>Clonal Hematopoiesis and Inflammation - Make it stand out</image:title>
      <image:caption>Mice with Tet2-deleted blood cells have more emphysema after exposure to cigarette smoke and pIpC (top) or cigarette smoke alone (bottom) compared to those with Tet2 wild-type blood cells. (1)</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/4b933680-8d48-4e12-aadf-38bb72d84ccb/HLH_CHIP_Visual+Abstract.jpg</image:loc>
      <image:title>Clonal Hematopoiesis and Inflammation - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.millerlabmgh.org/approach</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2025-04-02</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/25a5593d-e941-4ba6-810d-364036585963/Approach_Models.jpg</image:loc>
      <image:title>Miller Lab's Approach to Science - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/d2686b4b-358e-4448-be13-bda74c5e8bd6/Approach_Screening.jpg</image:loc>
      <image:title>Miller Lab's Approach to Science - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/e2f885aa-1926-4ca2-915d-0f03cd0e2351/Approach_HumanGenetics.jpg</image:loc>
      <image:title>Miller Lab's Approach to Science - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.millerlabmgh.org/home</loc>
    <changefreq>daily</changefreq>
    <priority>1.0</priority>
    <lastmod>2025-04-02</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/9d2fa661-701c-455a-ac80-1fee56238aaf/Combined+Logos+4.jpg</image:loc>
      <image:title>Miller Lab at MGH Home Page - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/2ef0484a-0aaf-4782-a956-ea0908a3c346/Orthogonal+Approaches.jpg</image:loc>
      <image:title>Miller Lab at MGH Home Page - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1618497259178-6XJGK9GR6YAVBQL5L519/20140301_Trade-151_012-2.jpg</image:loc>
      <image:title>Miller Lab at MGH Home Page</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1607694583486-2PQT0LQ193RL7MCB6DX4/20140228_Trade+151_0046.jpg</image:loc>
      <image:title>Miller Lab at MGH Home Page</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1607694644871-IC85FNH781UNZSZEGHDR/Aro+Ha_0428.jpg</image:loc>
      <image:title>Miller Lab at MGH Home Page</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/76bb0e97-6f4e-420f-bfb2-3a3265be3cb9/NCI+Logo+100.jpg</image:loc>
      <image:title>Miller Lab at MGH Home Page</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/466916f5-90b8-4841-a6c3-56ddfef89ef1/Evans+Logo.jpg</image:loc>
      <image:title>Miller Lab at MGH Home Page</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/aef9aed5-b36e-4eb3-b097-f3619ecb26a4/acs-logo-new.png</image:loc>
      <image:title>Miller Lab at MGH Home Page</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/d62c9c0f-8000-4bc1-907b-a2de5a3c6025/ALA_Logo.png</image:loc>
      <image:title>Miller Lab at MGH Home Page</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/ebf37d35-0b16-4723-a62f-24d0e5193859/DOD+CDMRP.png</image:loc>
      <image:title>Miller Lab at MGH Home Page</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/13214984-3eb2-4fb2-974b-5532c4a86387/MGH+logo.png</image:loc>
      <image:title>Miller Lab at MGH Home Page</image:title>
    </image:image>
  </url>
  <url>
    <loc>https://www.millerlabmgh.org/diseases</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2025-04-02</lastmod>
  </url>
  <url>
    <loc>https://www.millerlabmgh.org/projects</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2025-04-02</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/1641589989090-AIBNJGOI1G2F3IDG2KRK/DDR+PPM1D.jpg</image:loc>
      <image:title>Projects in the Miller Lab</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/1641589937014-8WP6C7HKKLMTJ9BKAU7M/CHIP_COPD_Graphical_Abstract.png</image:loc>
      <image:title>Projects in the Miller Lab</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/1641590152725-M0YKCWWGNZZVDA8XUEF4/CHIP%2Bin%2BCART.jpg</image:loc>
      <image:title>Projects in the Miller Lab</image:title>
    </image:image>
  </url>
  <url>
    <loc>https://www.millerlabmgh.org/approach-bc</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2022-01-13</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/d2686b4b-358e-4448-be13-bda74c5e8bd6/Approach_Screening.jpg</image:loc>
      <image:title>Approach - BC - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/25a5593d-e941-4ba6-810d-364036585963/Approach_Models.jpg</image:loc>
      <image:title>Approach - BC - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/e2f885aa-1926-4ca2-915d-0f03cd0e2351/Approach_HumanGenetics.jpg</image:loc>
      <image:title>Approach - BC - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.millerlabmgh.org/clonal-hematopoiesis-and-inflammation-bc</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2022-01-13</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/92f02a6e-2edd-4ba7-9ac0-76aec824304a/Emphysema+Mice.jpg</image:loc>
      <image:title>Clonal Hematopoiesis and Inflammation - BC - Make it stand out</image:title>
      <image:caption>Mice with Tet2-deleted blood cells have more emphysema after exposure to cigarette smoke and pIpC (top) or cigarette smoke alone (bottom) compared to those with Tet2 wild-type blood cells. (1)</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/4b933680-8d48-4e12-aadf-38bb72d84ccb/HLH_CHIP_Visual+Abstract.jpg</image:loc>
      <image:title>Clonal Hematopoiesis and Inflammation - BC - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.millerlabmgh.org/diseases-bc</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2022-01-26</lastmod>
  </url>
  <url>
    <loc>https://www.millerlabmgh.org/home-bc</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2022-01-14</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/f300ab29-0c12-4c87-8790-2d3bac0c08da/Inst-Logos-Small.jpg</image:loc>
      <image:title>Home - BC - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/2ef0484a-0aaf-4782-a956-ea0908a3c346/Orthogonal+Approaches.jpg</image:loc>
      <image:title>Home - BC - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/b4590265-ada7-41d2-9c90-d9f169a36163/NCI+Logo+100.jpg</image:loc>
      <image:title>Home - BC - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/5f1d3db2-a739-49f3-8d44-0b429ce6b72b/Evans+Logo+100.jpg</image:loc>
      <image:title>Home - BC - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1618497259178-6XJGK9GR6YAVBQL5L519/20140301_Trade-151_012-2.jpg</image:loc>
      <image:title>Home - BC</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1607694583486-2PQT0LQ193RL7MCB6DX4/20140228_Trade+151_0046.jpg</image:loc>
      <image:title>Home - BC</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1607694644871-IC85FNH781UNZSZEGHDR/Aro+Ha_0428.jpg</image:loc>
      <image:title>Home - BC</image:title>
    </image:image>
  </url>
  <url>
    <loc>https://www.millerlabmgh.org/positions-bc</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2022-01-13</lastmod>
  </url>
  <url>
    <loc>https://www.millerlabmgh.org/ppm1d-and-the-dna-damage-response-bc</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2022-01-13</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/f4d94013-373f-4312-9602-389495f24eb5/CHIP+in+CART.jpg</image:loc>
      <image:title>PPM1D and the DNA Damage Response - BC - PPM1D Mutations Are Common after Chemotherapy</image:title>
      <image:caption>Numerous studies have now confirmed that individuals with clonal hematopoiesis, myelodysplastic syndrome (MDS), or acute myeloid leukemia (AML) who have previously been exposed to chemotherapy or radiation are significantly more likely to have a mutation in a gene involved in the DNA damage response (DDR). Among this group of genes, PPM1D is the most-commonly mutated, with recurrent truncating mutations occurring in the c-terminus of the protein (1).</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/bd8bfe9e-a57c-4ca9-aa3f-3a7fca23d5ae/PPM1D+Homology+Model.jpg</image:loc>
      <image:title>PPM1D and the DNA Damage Response - BC - PPM1D Truncations Impair Degradation</image:title>
      <image:caption>We have previously shown that the c-terminus of PPM1D encodes for a degradation signal by the proteasome. Therefore, loss of the c-terminus of PPM1D via truncating mutations impair proteasomal degradation and increase intracellular levels of the protein. These elevated levels in turn suppress the DNA damage response and p53 activation allowing cells harboring these truncating mutations to be more resistant to chemotherapy relative to non-mutant cells (2).</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/9f8f7433-8f68-4227-8567-cf0bca8c0caa/DDR+PPM1D.jpg</image:loc>
      <image:title>PPM1D and the DNA Damage Response - BC - PPM1D as a Therapeutic Target in Cancer</image:title>
      <image:caption>We have now developed numerous new tools to interrogate these findings and are now working to more deeply explore numerous aspects of PPM1D biology, ranging from fundamental structure-functional studies of PPM1D to therapeutic studies in vivo. We believe that these lines of inquiry are required to understand the biology of PPM1D, the stem cell response to genotoxic stress, and the potential of PPM1D as a drug target in cancer.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.millerlabmgh.org/projects-bc</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2022-01-13</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/1641589989090-AIBNJGOI1G2F3IDG2KRK/DDR+PPM1D.jpg</image:loc>
      <image:title>Projects - BC</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/1641589937014-8WP6C7HKKLMTJ9BKAU7M/CHIP_COPD_Graphical_Abstract.png</image:loc>
      <image:title>Projects - BC</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/1641590152725-M0YKCWWGNZZVDA8XUEF4/CHIP%2Bin%2BCART.jpg</image:loc>
      <image:title>Projects - BC</image:title>
    </image:image>
  </url>
  <url>
    <loc>https://www.millerlabmgh.org/mutational-landscape-bc</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2022-01-13</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/548bdc85-a638-465d-8009-0830dd6f168b/CHIP+as+Screen.jpg</image:loc>
      <image:title>Mutational Landscape - BC - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/0278c112-171c-4141-a215-abd790df41b5/CHIP+in+CART.jpg</image:loc>
      <image:title>Mutational Landscape - BC - Clonal Hematopoiesis, MDS, Leukemia, and Cancer Therapy</image:title>
      <image:caption>In patients heavily pretreated for lymphoma or myeloma, we found that exposure to chemotherapy and radiation selects for mutation in genes involved in the DNA damage response including PPM1D and TP53 whereas exposure to immune checkpoint blockade does not (1,2). We are extending these studies to understand how these mutations ultimately lead to the development of myelodysplastic syndrome and leukemia.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.millerlabmgh.org/team-bc</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2022-01-13</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/4adcf23d-ab98-4559-8297-5b89a5a47134/image-asset.jpeg</image:loc>
      <image:title>Team (- BC - Peter Miller, MD, PhD</image:title>
      <image:caption>Principal Investigator Peter Miller grew up in Atlanta, Georgia and moved to Cambridge, Massachusetts after high school where he completed his undergraduate degrees in Chemical Engineering and Biology at the Massachusetts Institute of Technology. He completed his MD and PhD at Harvard Medical School and Harvard University where he studied leukemia stem cell biology in the laboratories of Gary Gilliland and Benjamin Ebert. After graduation, he completed an internal medicine residency at Brigham and Women’s Hospital and a fellowship in Medical Oncology and Hematology at the Dana-Farber Cancer Institute / Massachusetts General Hospital combined program. Peter performed his postdoctoral work in Ben Ebert’s lab at the Dana Farber Cancer Institute and Broad Institute. His research focuses on the biology of myeloid malignancies and he is a member of the leukemia program at the Massachusetts General Hospital Center for Cancer Research.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/1641926445693-IN12ZFC3EBLIMY0E208I/Nicole+Smith.png</image:loc>
      <image:title>Team (- BC</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/1642010315719-E5DS7BM90AVY5KK3PHXP/cheryl+Crowley+photo.jpg</image:loc>
      <image:title>Team (- BC</image:title>
    </image:image>
  </url>
  <url>
    <loc>https://www.millerlabmgh.org/new-page</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2023-06-22</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/f4938b60-2ee4-41cf-86cf-2653c87ba54b/IMG_8227.jpg</image:loc>
      <image:title>Lab Fun</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/e9851342-a6df-4a00-877b-506392b4f5a9/IMG_8608.jpg</image:loc>
      <image:title>Lab Fun</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/8b4ba775-a1b3-4e0d-8a15-2a635ef1b2cd/IMG_1154.jpg</image:loc>
      <image:title>Lab Fun</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/25032955-ab9d-4412-a82b-41bd5e0230d7/IMG_1322.jpg</image:loc>
      <image:title>Lab Fun</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/91ed9f11-b0f5-4de1-adb2-7a2598dede9e/IMG_2188+%282%29.jpg</image:loc>
      <image:title>Lab Fun</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/f761bc01-df66-485f-aa75-d178c3917c10/IMG_1522.jpg</image:loc>
      <image:title>Lab Fun</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/ff4a3b7e-4f42-4372-bc4f-2c94ce271f2e/IMG_1420.jpg</image:loc>
      <image:title>Lab Fun</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/4468b452-5713-4333-877b-130d8b5f481d/IMG_1399.jpg</image:loc>
      <image:title>Lab Fun</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/e8aa27c2-0833-4811-923d-1d8b04ca94a2/IMG_0064.jpg</image:loc>
      <image:title>Lab Fun</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/a846d648-4d52-49bc-a94d-571ee6501aee/IMG_2024_07_19-13_19_32_1810_E6B4E7E1.jpg</image:loc>
      <image:title>Lab Fun</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/e3fc3962-71bf-46dd-9107-4c29e99b62f8/IMG_1881+%281%29.jpg</image:loc>
      <image:title>Lab Fun</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/ac517a74-0d7c-4bc5-b6f8-8c22d68142cd/IMG_1891.jpg</image:loc>
      <image:title>Lab Fun</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/301312be-b893-4fca-bef6-eafb9c38854f/PHOTO-2023-04-20-16-36-32.jpg</image:loc>
      <image:title>Lab Fun</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/debd423a-6d53-49eb-a039-3c30ab8bfc6c/IMG_2212.jpg</image:loc>
      <image:title>Lab Fun</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/d2c2ba04-4c50-417d-8ce8-009a56490963/IMG_2405.jpg</image:loc>
      <image:title>Lab Fun</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/8a8b5fae-e753-4fa6-b721-9df159a6126a/IMG_2496.jpg</image:loc>
      <image:title>Lab Fun</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/f72bfb9e-fbc0-4ecb-84ac-35491bba612d/IMG_20230516_134527_1.jpg</image:loc>
      <image:title>Lab Fun</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/8b05d3ab-2834-43c1-a8ac-3d2c4e079cbe/Image+from+iOS.jpg</image:loc>
      <image:title>Lab Fun</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/5a112233-4fdf-4440-afde-61f140640e64/IMG_2821.jpg</image:loc>
      <image:title>Lab Fun</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/6b681a70-68f2-4e6f-91d5-a66752f3faa3/63f069e4-ffb1-41b1-b9f4-957ec4ab525e.jpg</image:loc>
      <image:title>Lab Fun</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/d28a055a-7cba-4af3-863e-d6811f01ad19/IMG_4829.jpg</image:loc>
      <image:title>Lab Fun</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/9bf95270-d99a-487f-8aac-6eb7231a12af/IMG_4680.jpg</image:loc>
      <image:title>Lab Fun</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/d3003c67-ea8a-475e-b43b-d9e90cd23706/IMG_4725.jpg</image:loc>
      <image:title>Lab Fun</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/bffa7b19-732e-42a5-9b75-0d0d4d5cc235/IMG_1084.jpg</image:loc>
      <image:title>Lab Fun</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/d0974f2a-4560-4544-9daf-a1d248b4da74/IMG_4994.jpg</image:loc>
      <image:title>Lab Fun</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/097285a9-fa89-400f-bbe9-e340f7c03176/IMG_4109.jpg</image:loc>
      <image:title>Lab Fun</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/5e0fd9fc-5316-467c-a215-56a042ef1b10/IMG_3801.jpg</image:loc>
      <image:title>Lab Fun</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/0c0d8d6d-46d0-494a-8f5d-1e908a6cbe1a/IMG_5103.jpg</image:loc>
      <image:title>Lab Fun</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/87023864-4302-41d9-9ff6-c60524c4761c/IMG_4028.jpg</image:loc>
      <image:title>Lab Fun</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/d96ec2ab-cfab-48cd-adde-cf9cec752e0e/IMG_5124.jpg</image:loc>
      <image:title>Lab Fun</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/8897c842-5ed6-4a2f-87e9-f2298393462e/IMG_3993.jpg</image:loc>
      <image:title>Lab Fun</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/ceda1e31-6674-4e0f-975b-57d0f1404c73/IMG_5046.jpg</image:loc>
      <image:title>Lab Fun</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/61d85cf1769e7f2366c3dc0d/700a7b65-55bd-42da-9cd5-9358b9d081ba/IMG_4098.jpg</image:loc>
      <image:title>Lab Fun</image:title>
    </image:image>
  </url>
</urlset>

